genetic and molecular aspects of helicobacter pylori in gastritis, pre -cancerous conditions and gastric adenocrcinoma

gastric adenocarcinoma is a common malignancy with high rate among other cancers in the world and many ethological causes have been introduced for which helicobacter pylori, as a gram-negative bacterium has been considered as an important pathological facilitating factor. this agent is also associated with more different digestive diseases, such as gastritis, peptic ulcer, mucosa-associated lymphoid tissue lymphoma. recently some molecular aspects have been described by scientists which show role of some apoptotic genes and proteins for example:p53, bcl2 ,c-myc and rb-suppressor systems in h pylori pathogenesis .also the relationship between nitric oxide( nosi genotype) with h pylori genes has been demonstrated in some studies, this mini-review has been aimed to explain better these  genetically aspects of pylori pathogenesis.